Pushing the Boundaries of Super-Resolution Microscopy

I develop novel computational methods and algorithms that enable imaging at the nanoscale — from single molecule localization to ultrasound super-resolution. My work combines optical physics, signal processing, and deep learning to solve challenging problems in biomedical imaging.

News
Jan 2026 — Released npcloud-python v1.0: NP-Cloud drift correction for SMLM 2025 — Contributed to NAIRR-SMLM benchmark datasets for AI research 2024 — Exploring deep learning approaches for PSF engineering Ongoing — Open to research collaborations in computational imaging

Research Areas

My research lies at the intersection of optics, computation, and biology. I focus on developing methods that extract maximum information from microscopy data.

Ultrasound Localization Microscopy

Applying super-resolution concepts to ultrasound imaging for visualization of microvasculature and blood flow at unprecedented resolution.

ULMMicrobubbleFlow Field

Deep Learning for Microscopy

Leveraging neural networks for image reconstruction, denoising, segmentation, and super-resolution in microscopy.

CNNSegmentationReconstruction

PSF Modeling & Engineering

Modeling and engineering point spread functions for 3D localization, including scalar and vectorial models.

3D PSFVectorialAberration

Image Analysis & Quantification

Quantitative analysis tools for microscopy: velocimetry, segmentation, and statistical methods.

VelocimetryStatisticsAnalysis

Selected Publications

2026

NP-Cloud: A Robust Drift Correction Method for Single Molecule Localization Microscopy

Tai-Long Chen et al.

In preparation
Ongoing

Research in Computational Super-Resolution and Deep Learning for Microscopy

Tai-Long Chen et al.

Active research projects
Full publication list is being updated. Please check back soon or visit my GitHub for the latest work.

Open Source Projects

I believe in open science. Here are some of my notable repositories and tools available on GitHub.

segmentation

Image segmentation tools and algorithms for microscopy data analysis.

Python

dataset

Curated datasets for microscopy research and algorithm benchmarking.

Data

PALA

OPUS-PALA & LOTUS tools for ultrasound localization microscopy.

MATLAB

NAIRR-SMLM

SMLM benchmark datasets for AI research, training, and education.

Benchmark

BasicSR

Image restoration toolbox: EDSR, ESRGAN, SwinIR and more.

Python

Skills & Toolbox

Programming Languages

PythonExpert
MATLABExpert
JuliaProficient
C++ / CUDAIntermediate
JavaScriptBasic

Frameworks & Tools

PyTorch
NumPy
SciPy
OpenCV
Matplotlib
Pandas
scikit-learn
Jupyter
CUDA
ImageJ
Git
Docker

Domain Expertise

Single Molecule Localization Microscopy PSF Modeling & Engineering Super-Resolution Imaging Ultrasound Localization Microscopy Deep Learning for Imaging Image Reconstruction Signal Processing Computational Optics Biomedical Imaging

Curriculum Vitae

Present

Research in Computational Imaging

Developing novel algorithms for super-resolution microscopy, drift correction, and deep learning approaches for biomedical imaging.

2023 - Present

Open Source Contributor

Active contributor to open source projects in microscopy and image processing. Maintainer of npcloud-python and related tools.

Full CV available upon request.

Request CV

Get In Touch

I'm always interested in research collaborations, discussing new ideas in computational imaging, or opportunities in microscopy and deep learning.

Don't hesitate to reach out — whether you have a question about my work, want to collaborate, or just want to say hello.